Tuesday, November 19, 2024

"How sugar affects the brain"


 

The Sweet Science of Sugar and Its Effect on the Brain

Picture warm, gooey cookies, crunchy candies, velvety cakes, waffle cones piled high with ice cream. Is your mouth watering? Are you craving dessert? Why? What happens in the brain that makes sugary foods so hard to resist? Sugar is a general term used to describe a class of molecules called carbohydrates, and it's found in a wide variety of food and drink. Just check the labels on sweet products you buy. Glucose, fructose, sucrose, maltose, lactose, dextrose, and starch are all forms of sugar. So are high-fructose corn syrup, fruit juice, raw sugar, and honey. And sugar isn't just in candies and desserts, it's also added to tomato sauce, yogurt, dried fruit, flavored waters, or granola bars. Since sugar is everywhere, it's important to understand how it affects the brain. What happens when sugar hits your tongue? And does eating a little bit of sugar make you crave more? You take a bite of cereal. The sugars it contains activate the sweet-taste receptors, part of the taste buds on the tongue. These receptors send a signal up to the brain stem, and from there, it forks off into many areas of the forebrain, one of which is the cerebral cortex. Different sections of the cerebral cortex process different tastes: bitter, salty, umami, and, in our case, sweet. From here, the signal activates the brain's reward system. This reward system is a series of electrical and chemical pathways across several different regions of the brain. It's a complicated network, but it helps answer a single, subconscious question: should I do that again? That warm, fuzzy feeling you get when you taste Grandma's chocolate cake? That's your reward system saying, "Mmm, yes!" And it's not just activated by food. Socializing, sexual behavior, and drugs are just a few examples of things and experiences that also activate the reward system. But overactivating this reward system kickstarts a series of unfortunate events: loss of control, craving, and increased tolerance to sugar. Let's get back to our bite of cereal. It travels down into your stomach and eventually into your gut. And guess what? There are sugar receptors here, too. They are not taste buds, but they do send signals telling your brain that you're full or that your body should produce more insulin to deal with the extra sugar you're eating. The major currency of our reward system is dopamine, an important chemical or neurotransmitter. There are many dopamine receptors in the forebrain, but they're not evenly distributed. Certain areas contain dense clusters of receptors, and these dopamine hot spots are a part of our reward system. Drugs like alcohol, nicotine, or heroin send dopamine into overdrive, leading some people to constantly seek that high, in other words, to be addicted. Sugar also causes dopamine to be released, though not as violently as drugs. And sugar is rare among dopamine-inducing foods. Broccoli, for example, has no effect, which probably explains why it's so hard to get kids to eat their veggies. Speaking of healthy foods, let's say you're hungry and decide to eat a balanced meal. You do, and dopamine levels spike in the reward system hot spots. But if you eat that same dish many days in a row, dopamine levels will spike less and less, eventually leveling out. That's because when it comes to food, the brain evolved to pay special attention to new or different tastes. Why? Two reasons: first, to detect food that's gone bad. And second, because the more variety we have in our diet, the more likely we are to get all the nutrients we need. To keep that variety up, we need to be able to recognize a new food, and more importantly, we need to want to keep eating new foods. And that's why the dopamine levels off when a food becomes boring. Now, back to that meal. What happens if in place of the healthy, balanced dish, you eat sugar-rich food instead? If you rarely eat sugar or don't eat much at a time, the effect is similar to that of the balanced meal. But if you eat too much, the dopamine response does not level out. In other words, eating lots of sugar will continue to feel rewarding. In this way, sugar behaves a little bit like a drug. It's one reason people seem to be hooked on sugary foods. So, think back to all those different kinds of sugar. Each one is unique, but every time any sugar is consumed, it kickstarts a domino effect in the brain that sparks a rewarding feeling. Too much, too often, and things can go into overdrive. So, yes, overconsumption of sugar can have addictive effects on the brain, but a wedge of cake once in a while won't hurt you.



"Nutrition MYTHS Experts Wish Would Die"

 


Super Interesting Article on Nutrition Myths

Super interesting article just came out in the New York Times where they asked 10 nutrition scientists about their pet peeves, the common nutrition myth they wish would die. I already went through, I agree with some, I have questions about others, so let's take a look.


Myth #1: Fresh Fruits and Vegetables Are Always Healthier Than Canned, Frozen, or Dried

Myth number one, fresh fruits and vegetables are always healthier than canned, frozen, or dried. Yeah, I agree this is a myth, there are specific studies looking at this and measuring, and in general, freezing is pretty good at keeping nutrient content. Sometimes it's even better than buying fresh because in reality, we don't eat everything the day we buy it; it sits in the fridge for a couple of days, and by the time we eat it, the frozen product may actually have more nutrition preserved because it degrades slower. So, studies have actually measured and shown that. Now, leafy greens may be a bit of an outlier—freezing things like spinach can cause some nutrients, like some vitamins, for example, their level can come down by 25% or so. But depending on how long your vegetables sit in the fridge if you buy them fresh, the difference between refrigerated and frozen isn't that big. The other factor, of course, is waste. Sometimes vegetables sit in the fridge too long, they go bad, and we have to toss them, so buying frozen can actually result in saving some kaching and of course less environmental impact because that's less food that gets produced only to be thrown away. Now, one caveat of preserved food are the additives, canned beans for example can come with a lot of sodium added, and canned fruit sometimes comes in this sugary, syrupy water, so those are some things to look out for. But in general, frozen fruits and vegetables are pretty good options.


Myth #2: All Fat Is Bad

Myth number two, all fat is bad. Yeah, this is a relic from the 20th century, from last century, and I still see this here and there on social media. I think what happens is sometimes people lose weight on a low-fat diet, and then they get told, "See, it was the fat you took out that's unhealthy." It's not. We can lose weight on all kinds of diets, it doesn't necessarily mean that the thing we left out is automatically unhealthy; you just cut out a source of calories. Eating too many calories is bad for us, whether it's from fat or not. One problem with the fat phobia is people can be drawn to buy and consume ultra-processed foods labeled low-fat or no fat added and end up eating a lot of refined carbohydrates. I know most viewers of this channel wouldn't fall for that, but that's a pretty common problem. Now, some people like to eat low-fat diets mostly from whole foods, and that's completely fine as a personal preference, but we don't have to fear fat. The question is not so much the amount of fat, it's the type of fat. As the professor of medicine from UCLA who contributed this section writes, saturated and trans fats can increase your risk of heart disease or stroke, while healthy fats like mono and polyunsaturated fats help reduce risk. So, vegetable oils, avocados, nuts, seeds, fatty fish, etc. We've actually covered this topic in a lot of previous content; we went over all the evidence, all the cohort studies, all the trials, so we're not going to spend too much time on this, we're going to move on to myth number three.


Myth #3: Calories In, Calories Out Is the Most Important Factor for Long-Term Weight Gain

Myth number three, calories in, calories out is the most important factor for long-term weight gain. Okay, so this one I found strange. I read it several times, and it's still not clear to me exactly what he means. This one was contributed by Dariush Mozaffarian, who's a professor of nutrition at Tufts, and he says the critical thing for weight loss is avoiding ultra-processed foods. I agree with that in general, and he recommends a shift from counting calories to prioritizing healthy eating overall—quality over quantity. Agree 100%. Focusing on healthy foods tends to take care of the calorie problem. I just think the title is weird, how he worded it, the myth he chose, right? Calories in, calories out being the most important factor for weight gain—that's the top myth for him. It's true that conscious focus on calories doesn't seem helpful for most people, but that doesn't mean calories in, calories out isn't a key factor. In fact, we know that eating ultra-processed foods leads to overconsumption of calories, so they're not mutually exclusive. I think his wording conflates best approaches with what the underlying physiological factors might be. But let me know in the comments if you disagree and if you interpret his words differently. I agree with his bottom line though: minimizing ultra-processed foods in general and focusing on quality foods. It's just I would have worded the myth as something like, "Focusing on calories is the best approach for weight loss" or "Trying to eat less is the best approach for weight loss," something like that, and then explain that it's better to focus on eating better instead of eating less.


Myth #4: People With Type 2 Diabetes Shouldn't Eat Fruit

Myth number four, people with type 2 diabetes shouldn't eat fruit. Yeah, this is a pretty common one to hear. I think it comes from fruit containing sugars, even though they're natural sugars in the food matrix with fiber. But there's this notion that sugars of any source are bad for diabetes. I don't have a 100% black-and-white position on this. The balance of evidence doesn't seem to support that whole fruit is a problem for diabetics. We know people who eat more fruit tend to have a lower risk of developing type 2 diabetes, and type 2 diabetics who eat more fruit tend to have a lower risk of complications and even mortality. Now, we can always argue, well, maybe it's some other healthy habit that they have; it's not the fruit itself. So we also want to see, ideally, when available, some randomized trials. I've seen a few trials specifically looking at whole fruit separate from vegetables in a population with type 2 diabetes. This one, for example, told half the participants to eat a bit more fruit and the other half to eat a little bit less, and after three months they didn't see a significant difference in body weight or hemoglobin A1c, which is an average of the glucose levels over the long run. Several caveats of this study that lower my confidence a little, for example, the difference in fruit intake was subtle. Before the trial, they ate about 190 grams of fruit a day on average, which is the equivalent of a medium apple, and during the trial, one group went up to 320 grams a day, and the other came down to 135, so it's like comparing an apple and a half to two-thirds of an apple. So the trial is saying that in the background of a whole dietary pattern, eating a little more than an apple a day versus a little less than an apple in type 2 diabetics doesn't seem to make a big difference for glucose levels, and I have no trouble believing that. I'm not knocking the trial, this is a common hurdle—getting people to achieve significantly different levels of intake, what we call contrast of exposure. In an ideal world, we'd like to see one group eat no fruit or close to it, and the other group eat five or six pieces a day, and if we still see no difference, then that's pretty compelling that fruit by itself doesn't seem to play a huge role. Another source of uncertainty is they don't specify what people ate instead of the fruit. Fruit normally replaces other desserts or snacks, so people cutting back on fruit might eat something worse instead. Another factor to bear in mind is heterogeneity. Just saying "fruit" is a very large category, I think it's entirely possible that different fruits may have different effects, particularly for people with defective metabolism like diabetics. For example, in this study, blueberries, bananas, apples, and pears, and grapefruit were associated with lower type 2 diabetes risk. Peaches and oranges with no significant difference, and cantaloupe was associated with a higher risk of type 2. Usual caveats apply—I'm not saying this demonstrates cause and effect and cantaloupes make us diabetic, but I think this raises the possibility of heterogeneity between fruit types. So what about trials looking at specific fruits? I've seen some with berries, for example, and they generally seem to improve metabolic parameters like glucose, insulin, and inflammatory markers, both in diabetics and in healthy people. I've also seen some trials with grapes meta-analyzed, and they don't find a significant effect on glucose or insulin of whole grapes, although the trials that looked at whole grapes were not in diabetics, they were in healthy people. Also seen a couple trials with dates, generally finding lower glycemia and no significant change in hemoglobin A1c. So the data I've seen doesn't point to a clear issue with fruit in type 2 diabetics, with the usual uncertainty around types of fruit and amount and replacement, etc. As we discussed recently with Dr. Nicola Guess, the main factor for type 2 diabetes remission is weight loss, and people have different strategies for that. Some people put type 2 diabetes in remission with high fruit diets, others with low carb diets where they have some low-carb fruits like berries and they generally avoid more sugary fruits like mangoes and bananas. Both approaches can work, at least for weight loss and type 2 diabetes remission. So overall, I agree the statement "diabetics shouldn't eat fruit" is a myth.

"Mindfulness Meditation - Relaxation"

 

Guided Meditation

Welcome to your guided meditation. All you have to do is find a quiet spot where you can get into a comfortable position, either sitting up or lying down, and please don't do this while you're driving, because hopefully you might find it a bit relaxing. At some point, I'll offer you to close your eyes; you don't have to do that if you don't feel comfortable, but just follow my voice and enjoy. So, finding yourself in a comfortable position, I want you to take a couple of slightly deeper breaths, and we're going to focus that spotlight of your attention on how it feels to breathe. Then in one of those out breaths, you can just allow your eyes to close and really draw your attention in to how it feels to breathe. When your mind wanders from your breath, that's normal. Just notice where your mind has gone and gently guide it back to refocus on the sensation of breathing. Just notice that natural rhythm of your breathing; notice which parts of your body move to enable you to breathe. Again, when your mind wanders, just notice where it's gone, and gently guide it back to focus on the breath. Notice that your body just does it for you. You don't need to try. Notice the temperature of the air that you're breathing, and notice the difference in the sensations between breathing in and breathing out. Then we're going to expand that spotlight of your attention to focus on the rest of the body. I just want you to notice different areas of your body. How does it feel to be sitting or lying down? Do you feel warm or cold? Just notice if there's any tension anywhere, any pains. We're not trying to change any of those, just noticing them, what they are in this moment. Just allow them to be there and keep returning to the breath. Then I want you to notice what emotions you might have in the room with you here now. Just notice what you feel. And then, if you have a name for that emotion, I want you to notice where you sense that feeling in your body, where you feel it. Still breathing, that might be a feeling that is pleasant, or it might be a feeling that's unpleasant. Either way, we're going to allow that feeling to be here for this moment, just noticing that it's an experience within you. It's not who you are. It's a sensation, but not the fabric of your body. Then I want you to place one hand on the part of your body where you feel that emotion, and just allow that palm to radiate warmth and loving-kindness to that emotional experience. Now, that warmth of your palm just represents your kindness to yourself. If your mind wanders, that's normal. That's okay. Just notice where your mind has gone and come back to the here and now, noticing that rhythm of your breathing and the emotions in your body. Then, drawing the attention back from your body and the emotion, just your breathing once again. Again, noticing that physical movement happens every time you breathe, allowing for that sensation of relief with each out breath. If your jaw is clenched together, allow that to open slightly. And again, if your mind wanders, just notice and gently guide it back to the here and now. Then I want you to become aware again of how it feels to be sitting or lying. Notice which parts of your body are in contact with the chair or the bed, wherever you are. Maybe the feet on the floor. Just notice the sensation of your surroundings. Then expand that awareness again to the sounds that you can hear around you, and take some slightly deeper breaths one more time when you're ready. In one of those out breaths, if you've had your eyes closed, just allow your eyes to open, familiarize yourself with the room one more time. Notice what you can see, what you can hear, and what you can touch. I hope you enjoyed this meditation. A useful exercise can sometimes be to just reflect on where your mind wandered to while you were trying to be present. Not trying to change that, just noticing it as a good learning experience. I hope you all enjoyed this. Let me know in the comments how you found it and whether you'd like me to do some more of these.